Structural mutation analysis server

Mut-Map: map cancer mutations onto protein structures

Mut-Map is a computational pipeline for mapping COSMIC cancer-associated mutations onto experimentally determined and AlphaFold protein structures. It annotates mutation positions across structural environments including core residues, protein interfaces, DNA-binding regions, ligand-binding sites, zinc-binding residues, peptides, disorder regions, solvent accessibility, and DSSP secondary-structure features.

Developed by Ali F Alsulami
COSMIC mutation mapping PDB + AlphaFold structures Interfaces and ligands SASA, disorder, DSSP
1

Collect structures

Retrieves matching PDB entries, prepares AlphaFold models, and organizes files by UniProt and structure ID.

2

Map mutations

Maps COSMIC amino-acid substitutions to available structures and calculates structural context annotations.

3

Visualize results

Generates final CSV outputs, plots, and interactive Mol* structure views for residue-level inspection.