The form on this page exclusively accepts Homo sapiens (Human) UniProt IDs. After submission, the application initiates a pipeline called Map-Mut, processing the input and presenting the results.

The results page illustrates the PDB coverage for the selected gene, the percentage of the disorder region affected, and the percentage of mutations within that region. Below is a table mapping PDB IDs to the chosen gene and indicating mutations within each PDB entry. The table displays the position and frequency of each mutation. Additionally, users have the option to download the complete CSV file from this page.

Selecting the PDB name from the result page will redirect users to a new page dedicated to the chosen PDB structure. This PDB page provides detailed information, including mutations mapped to the selected PDB, graphical representations depicting mutation locations, and the utilization of the MolStar viewer to visualize the selected PDB structure. Furthermore, users can access a disorder table that highlights mutations present within the designated region.

Upon scrolling down the PDB page, users encounter the MolStar viewer, which showcases the selected PDB structure alongside mutations mapped within the disorder region. Notably, access to the disorder region is restricted to selecting the AlphaFold Model on the Result page.

The MolStar presents the three-dimensional (3D) structure of proteins, it has multiple features such as presenting the target structure sequence calculating the interactions such as hydrogen bonding, Pi stacking, etc between selected resides or ligand. All these features will give the end-user a better understanding of the protein structure. Extensive user guide of how to use the MOL* can be fount at: https://www.rcsb.org/3d-view/molstar/help/getting-started